[LRC Network] Fw: pubmed Search Results - new articles on EBM ( July 08, 2006 )
Posted июль 25th, 2006 by Ibra
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1: Am J Gastroenterol. 2006 Jun 30; [Epub ahead of print] Related Articles, Books, LinkOut
Guidelines Do Help Change Behavior in the Management of Osteoporosis by Gastroenterologists.
Kane S, Reddy D.
Department of Medicine, University of Chicago, Chicago, Illinois.
BACKGROUND AND AIMS: The American College of Gastroenterology supported the development of evidence-based guidelines for the management of osteoporosis in inflammatory bowel disease. Our aim was to determine the short-term impact of the guidelines on practice patterns. METHODS: Two hundred clinicians were surveyed prior to and 3 and 6 months after the guidelines were disseminated. The number of bone density scans ordered by these physicians was also determined before and 3 and 6 months after guidelines were distributed. RESULTS: At the end of 3 months, only 20% of subjects admitted to having read the guidelines. There was a significant number of subjects who felt more comfortable treating osteoporosis (20%vs 10% prior to dissemination of the guidelines [p= 0.05]). There was a 150% increase in the number of bone density scans ordered during that time by these 40 practitioners. After 6 months, another 15% for a total of 35% of subjects had read the guidelines. The number of subjects who were comfortable treating osteoporosis increased to 25% from 10% (p < 0.001). The number of bone density scans increased by 100% in these practices. CONCLUSIONS: Although a minority of subjects read the guidelines, there was a significant impact on the short-term practice patterns of these practitioners.
PMID: 16817840 [PubMed - as supplied by publisher]
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2: Plast Reconstr Surg. 2006 Jul;118(1):248-52. Related Articles, Books, LinkOut
Vitamin E: patterns of understanding, use, and prescription by health professionals and students at a University Teaching Hospital.
Curran JN, Crealey M, Sadadcharam G, Fitzpatrick G, O'Donnell M.
Department of Plastic and Reconstructive Surgery, St. Vincent's University Hospital, Dublin 4, Ireland. curranjn@eircom.net
BACKGROUND: Vitamin E is a generic term used to describe the many derivatives of tocol and tocotrienol. It is the major lipid-soluble antioxidant in the skin and has been used as treatment for many skin conditions, including scarring. Studies have shown that vitamin E provides no benefit to the cosmetic outcome of scars. METHODS: The authors constructed and distributed a questionnaire among staff and students at their institution. Their aim was to determine patterns of use and prescription of vitamin E among staff and students and to determine the understanding of the properties and biological functions of vitamin E. RESULTS: Questionnaires were completed by 208 staff and students, including 110 nonconsultant hospital doctors (52.89 percent), 61 nurses (29.33 percent), and 27 medical students (12.98 percent). Nearly 68 percent thought that vitamin E could be of use in improving the cosmetic appearance of scars, while 25 percent actually recommended vitamin E to patients to improve the cosmetic outcome of scars. Just under 40 percent were aware of the biological function of vitamin E, while 16.35 percent thought vitamin E had absolutely no effect on scarring. Of respondents, 21.64 percent had used vitamin E for their own scars; 31.11 percent of these said it was suggested by a doctor, while 6.67 percent said a pharmacist suggested it. CONCLUSIONS: Without scientific basis, health professionals continue to recommend vitamin E for use on scars. Such recommendations should not be made in the absence of evidence-based medicine.
PMID: 16816703 [PubMed - in process]
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3: J Nurs Care Qual. 2006 Jul-Sep;21(3):195-202. Related Articles, Books, LinkOut
Translating Research Into Evidence-based Nursing Practice and Evaluating Effectiveness.
Coopey M, Nix MP, Clancy CM.
Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Md.
PMID: 16816597 [PubMed - in process]
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4: J Med Ethics. 2006 Jul;32(7):430-4. Related Articles, Books, LinkOut
Non-commercial clinical trials of a medicinal product: can they survive the current process of research approvals in the UK?
Sheard L, Tompkins CN, Wright NM, Adams CE.
Centre for Research in Primary Care, 71-75 Clarendon Road, Leeds LS2 9PL, England. l.sheard@leeds.ac.uk.
Over recent years, considerable attention has been paid to the National Health Service (NHS) research governance and ethics approvals process in the UK. New regulations mean that approval from the Medicines and Healthcare Products Regulatory Agency (MHRA) is now also needed for conducting all clinical trials. Practical experience of gaining MHRA and sponsorship approval has yet to be described and critically explored in the literature. Our experience, from start to finish, of applying for these four approvals for a multicentre randomised controlled trial of two licensed drugs for opiate detoxification in the prison setting is described here. In addition, the implications of the approvals process for research projects, particularly clinical trials, in terms of time and funding, and also indirect implications for NHS patients are discussed. Inconsistencies are discussed and suggestions that could improve and streamline the overall process are made. The current approvals process could now be hindering non-commercial clinical trials, leading to a loss of important evidence-based medical information.
PMID: 16816046 [PubMed - in process]
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5: Respir Med. 2006 Jun 28; [Epub ahead of print] Related Articles, Books, LinkOut
A critical evaluation of the guidelines of obstructive lung disease and their implementation.
Gulsvik A, Gallefoss F, Dirksen A, Kinnula V, Gislason T, Janson C.
Department of Thoracic Medicine, Institute of Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway.
Guidelines or recommendations for diagnosis and treatment of obstructive lung diseases defined as asthma and/or chronic obstructive pulmonary disease (COPD) have been numerous in the Nordic countries during the last 25 years. A better-shared care between on one side the general practitioners or chest physicians and on the other side the patients and their closest surroundings of care has to be implemented in future guidelines. Guidelines are based on efficacy and not effectiveness studies, and do not properly focus the process of behavioural changes of health care professionals and patients. Primary care physicians treat the vast majority of patients with chronic airway disease of moderate severity. However, they find the evidence-based practice guidelines often complicated. Furthermore, less than 50% of the recommendations in guidelines may be evidence based. As rapid changes may occur in diagnosis and treatment options, future guidelines must be able to adapt to such rapid adjustments. No randomised studies are available on the effect of patient-relevant outcomes using guidelines on management of obstructive lung disease. More outcome research is necessary on both change of procedures and health endpoints after launching guidelines. Cost-effectiveness studies are important to make medical staff and administrative health care systems cooperate in the construction of future health care systems with both an improved medical and system quality.
PMID: 16814539 [PubMed - as supplied by publisher]
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6: J Subst Abuse Treat. 2006 Jul;31(1):25-39. Related Articles, Books, LinkOut
Disseminating evidence-based practices in substance abuse treatment: A review with suggestions.
Miller WR, Sorensen JL, Selzer JA, < a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Brigham+GS%22%5BAuthor%5D">Brigham GS.
Department of Psychology, MSC03 2220, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA.
Although substance abuse professionals are generally open to new and better therapeutic methods, most evidence-based treatments do not easily find their way into practice. Natural diffusion processes for innovations in substance abuse treatments are relatively informal and have yielded a widely acknowledged gap between science and community practice. This review focuses on methods for effectively disseminating new treatment methods into practice. Therapist manuals and one-time workshops are in themselves relatively ineffective in helping practitioners gain proficiency in new clinical approaches. Individual performance feedback and coaching improve the acquisition of clinical skills. Specific incentives for implementation may also be needed to encourage treatment providers, programs, and systems to adopt new approaches.
PMID: 16814008 [PubMed - in process]
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7: J Psychosom Res. 2006 Jul;61(1):123-8. Related Articles, Books, LinkOut
A survey of delirium guidelines in Europe.
Leentjens AF, Diefenbacher A.
Department of Psychiatry, Maastricht University Hospital, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
OBJECTIVE: The aim of this study was to investigate the existence and content of delirium guidelines of the national psychiatric associations in Europe. METHOD: A survey was sent by email to national coordinators of the European Association for Consultation-Liaison Psychiatry and Psychosomatics. RESULTS: Responses were obtained for 12 of the 14 countries that were approached. Of these 12 countries, only two national psychiatric associations reported having national delirium guidelines. The Dutch Psychiatric Association was the only national psychiatric association that had developed a comprehensive multidisciplinary guideline on the diagnosis and treatment of delirium. The German Association of Scientific Medical Societies has a comprehensive guideline on the treatment of alcohol withdrawal delirium, in which the German Society for Psychiatry, Psychotherapy, and Mental Disorders participated. In addition, the delirium guideline of the British Geriatrics Society and the guideline for alcohol withdrawal delirium of the German Neurological Society were mentioned by respondents. CONCLUSIONS: Although the development of evidence-based treatment guidelines is considered an important way to improve clinical practice, the national psychiatric associations of only two countries have such a guideline for the diagnosis and treatment of delirium. The advantages of supranational collaboration in the development of guidelines are stressed.
PMID: 16813854 [PubMed - in process]
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8: J Am Diet Assoc. 2006 Jun;106(6):925-45. Related Articles, Books, LinkOut
Position of the American Dietetic Association: individual-, family-, school-, and community-based interventions for pediatric overweight.
American Dietetic Association (ADA).
The American Dietetic Association (ADA), recognizing that overweight is a significant problem for children and adolescents in the United States, takes the position that pediatric overweight intervention requires a combination of family-based and school-based multi-component programs that include the promotion of physical activity, parent training/modeling, behavioral counseling, and nutrition education. Furthermore, although not yet evidence-based, community-based and environmental interventions are recommended as among the most feasible ways to support healthful lifestyles for the greatest numbers of children and their families. ADA supports the commitment of resources for programs, policy development, and research for the efficacious promotion of healthful eating habits and increased physical activity in all children and adolescents, regardless of weight status. This is the first position paper of ADA to be based on a rigorous systematic evidence-based analysis of the pediatric overweight literature on intervention programs. The research showed positive effects of two specific kinds of overweight interventions: a) multicomponent, family-based programs for children between the ages of 5 and 12 years, and b) multicomponent, school-based programs for adolescents. Multicomponent programs include behavioral counseling, promotion of physical activity, parent training/modeling, dietary counseling, and nutrition education. Analysis of the literature to date points to the need for further investigation of promising strategies not yet adequately evaluated. Furthermore, this review highlights the need for research to develop effective and innovative overweight prevention programs for various sectors of the population, including those of varying ethnicities, young children, and adolescents. To support and enhance the efficacy of family- and school-based weight interventions, community-wide interventions should be undertaken; few such interventions have been conducted and even fewer evaluated.
Publication Types:
a.. Practice Guideline
PMID: 16812927 [PubMed - in process]
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9: J Gen Intern Med. 2006 Jul;21(7):792-5. Related Articles, Books, LinkOut
International Clinical Epidemiology Network: an opportunity for SGIM international cooperation.
Tugwell P, Fletcher R, Fletcher S, Goldsmith C, Rahbar M, Robinson V, Runyan D, Sadowski L.
Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada. elacasse@uottawa.ca
The Canadian/American regional group of the International Clinical Epidemiology Network (INCLEN) invites SGIM members to join in an international network dedicated to improving health in low and middle-income countries and reducing health disparities in North America-not only because many goals and activities of the 2 organizations are compatible such as evidence-based medicine, mentoring, and training; but because collaboration between SGIM and INCLEN could strengthen both groups. With increasing brain drain from the developing world to the North, there is an ever-increasing need for academic contributions from the North to swing the balance toward brain gain for the South. SGIM members have the academic expertise to make an important contribution to global health. Participation and contribution from SGIM members is welcomed at the individual or organizational level. We invite you to explore possible partnership and collaboration.
PMID: 16808784 [PubMed - in process]
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10: J Gen Intern Med. 2006 Jul;21(7):735-44. Related Articles, Books, LinkOut
Antioxidants vitamin C and vitamin e for the prevention and treatment of cancer.
Coulter ID, Hardy ML, Morton SC, Hilton LG, Tu W, Valentine D, Shekelle PG.
RAND, Southern California Evidence-based Practice Center, Santa Monica, CA, USA. coulter@rand.org
OBJECTIVE: To evaluate the evidence of the supplements vitamin C and vitamin E for treatment and prevention of cancer. METHODS: Systematic review of trials and meta-analysis. DATA SOURCES AND MAIN RESULTS: Thirty-eight studies showed scant evidence that vitamin C or vitamin E beneficially affects survival. In the ATBC Cancer Prevention Study Group, no statistically significant effect of treatment was seen for any cancer individually, and our pooled relative risk (regardless of tumor type) for alpha-tocopherol alone was 0.91 (95% confidence interval [CI]: 0.74, 1.12). All cause mortality was not significant. In the Linxian General Population Trial, the relative risks for cancer death for vitamin C (combined with molybdenum) was 1.06 (95% CI: 0.92, 1.21) and for vitamin E (combined with beta-carotene and selenium) was 0.87 (95% CI: 0.76, 1.00). We identified only 3 studies that reported statistically significant beneficial results: vitamin C (in combination with BCG) was found to be beneficial in a single trial of bladder cancer and vitamin E (in combination with omega-3 fatty acid) increased survival in patients with advanced cancer. In the ATBC trial, in analyses of 6 individual cancers, the prevention of prostate cancer in subjects treated with alpha-tocopherol was statistically significant (RR=0.64, 95% CI: 0.44, 0.94). CONCLUSIONS: The systematic review of the literature does not support the hypothesis that the use of supplements of vitamin C or vitamin E in the doses tested helps prevent and/or treat cancer in the populations tested. There were isolated findings of benefit, which require confirmation.
PMID: 16808775 [PubMed - in process]
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11: J Gen Intern Med. 2006 Jun;21(6):656-60. Related Articles, Books, LinkOut
A clinician-educator's roadmap to choosing and interpreting statistical tests.
Windish DM, Diener-West M.
Department of Internal Medicine, Yale University School of Medicine, New Ha ven, CT, USA. donna.windish@yale.edu
As educators seek confirmation of successful trainee achievement, medical education must move toward a more evidence-based approach to teaching and evaluation. Although medical training often provides physicians with a general background in biostatistics, many are not prepared to apply these skills. This can hinder clinician educators as they wish to develop, analyze and disseminate their scholarly work. This paper is intended to be a concise educational tool and guide for choosing and interpreting statistical tests aimed toward medical education assessment. It includes guidelines and examples that clinician-educators can use when analyzing and interpreting studies and when writing methods and results sections of reports.
PMID: 16808753 [PubMed - in process]
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